A South African child born with HIV has surprised experts by appearing to be effectively cured of the AIDS virus after just a year of treatment, followed by 8½ years drug free.
Patients with HIV would normally need to stay on antiretroviral (ART) drugs for the rest of their lives to keep AIDS at bay. But this child, still off treatment and now almost 10 years old, has no signs of the disease.
This and other recent, isolated cases of remission have given additional hope to the 37 million people worldwide infected with the virus that causes AIDS.
Yet experts urged caution, saying the case is extremely rare and does not suggest a simple path to a cure.
“It’s a case that raises more questions than it necessarily answers,” said Linda-Gail Bekker, president of the International AIDS Society (IAS), which is holding its conference in Paris this week. “It does raise the interesting notion that maybe treatment isn’t for life. [But] it’s clearly a rare phenomenon.”
Over 19 million people on treatment
The child, whose name and gender were not disclosed, was part of a clinical trial in which researchers were investigating the effect of treating HIV-positive babies in the first few weeks of life, and then stopping and starting the ART medicines while checking whether their HIV was being controlled.
The United Nations HIV/AIDS agency said last week that 19.5 million people — more than half of the 37 million patients with HIV — are now on treatment. The vast majority of patients with HIV suffer an increase in the amount of the virus circulating in the body if they stop treatment, but this child was different, the South African researchers said.
“To our knowledge, this is the first case of sustained virological control from a randomized trial of ART interruption following early treatment of infants,” they said in a summary of findings presented at the IAS conference on Monday.
The baby contracted HIV from its mother. Treatment with ART started when the baby was almost nine weeks old but was interrupted at 40 weeks when the virus had been suppressed, and the child was monitored regularly for any signs of relapse.
“At age 9.5 years, the child was clinically asymptomatic,” the researchers said.
Sharon Lewin, an HIV expert at the University of Melbourne and co-chair of the IAS’s HIV Cure and Cancer forum, said the case raised possible insights into how the human immune system can control HIV replication when treatment is interrupted.
Yet in terms of the scientific search for a cure for HIV and AIDS, she told Reuters, it appeared only to confirm previous reports of similarly rare cases.
“We know that very rarely, people who have had treatment and stopped it are then able to control the virus.”
The HIV/AIDS pandemic has killed around 35 million people worldwide since it began in the 1980s.